welcome to oneFAPvoice- a positively charged Familial Adenomatous Polyposis community.
- join today!
Cancer Prevention Pharmaceuticals (CPP) and Mallinckrodt Announce Results from Pivotal Phase 3 Trial of CPP-1X/Sulindac in Patients With Familial Adenomatous Polyposis
Cancer Prevention Pharmaceuticals, Inc., a private biotech company developing novel therapeutics to prevent cancer and other diseases, and its partner Mallinckrodt Plc, a leading global specialty pharmaceutical company, today announced that CPP’s pivotal phase 3 clinical trial, CPP FAP-310, of the investigational drug CPP-1X/sulindac in patients with familial adenomatous polyposis (FAP), did not meet its primary endpoint. Specifically, the reduction of time to the first occurrence of an FAP-related event for the combination of CPP-1X (eflornithine) and sulindac (a nonsteroidal anti-inflammatory drug) did not reach statistical significance compared to the two control arms. CPP FAP-310 included only active comparator arms and was the largest and longest study ever conducted in patients with FAP.
“While we are disappointed that the CPP FAP-310 clinical trial did not achieve its primary endpoint, we are encouraged by the data that relate to important outcome measures,” said CPP CEO Jeff Jacob.
expertly curated content related to this topic
Rectal Epithelial Apoptosis in Familial Adenomatous Polyposis Patients Treated with SulindacBACKGROUND : Sulindac regresses colorect...
Coxib-inhibition of Duodenal Polyp Growth in FAPPreliminary data indicate a protective e...
Genetic Polymorphisms of Human Flavin Monooxygenase 3 in Sulindac-Mediated Primary Chemoprevention of Familial Adeno...PURPOSE : Sulindac is a nonsteroidal ant...
New treatment reduces precancerous polyps in hereditary cancer patientsInheriting a mutation in the APC gene le...
Clinical and Genomic Influence of Sulindac on Rectal Mucosa in Familial Adenomatous PolyposisPURPOSE : A study was performed to evalu...
Genetic Polymorphisms of Flavin Monooxygenase 3 in Sulindac-Induced Regression of Colorectal Adenomas in Familial Ad...Sulindac is a nonsteroidal antiinflammat...