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Fatty Diet Activates Oldest Branch of Immune System, Causing Intestinal Tumors
We found that specific types of high-fat diets – based on corn or coconut oils like those found in certain salad dressings and ice cream — are associated with increased tumor formation in a mouse model of intestinal cancer,” said co-senior author John Lambris, PhD, the Dr. Ralph and Sallie Weaver Professor of Research Medicine at Penn. “This model is particularly interesting because it resembles human familial adenomatous polyposis, a condition that carries an 80 percent risk of developing colorectal cancer in individuals with mutations in a tumor suppressor gene called Apc.
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