welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Researchers: Specific gene could predict colon cancer outcomes
Those studying and treating colon cancer will have a new way of looking at the disease thanks to research results from a study led by Dr. Timothy J. Yeatman, President and Director of Gibbs Cancer Center & Research Institute at Spartanburg Regional Healthcare System. The study, published in medical scientific journal “Nature Communications” in June, entitled “A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC,” focuses on the Adenomatous Polyposis Coli (APC), a gene that has long been considered the gatekeeper in the development of colon cancer. Yeatman, lead investigator at the Gibbs Cancer Center & Research Institute, along with Dr. Michael J. Schell of Moffitt Cancer Center in Tampa, Fla., performed extensive analysis of DNA sequencing from a large, human colon cancer database to identify a new, clinically-relevant role for APC, that is mutated in more than 70 percent of colon cancer cases. “The fact that APC mutation is so common would suggest that it wouldn’t have any other role than simply to initiate colon cancer,” Yeatman said. “But we found this not to be the case.” Starting with analyzing 1,321 cancer genes, the study results found that gene sequencing of APC and other associated genes reveals a prognostic effect that could help physicians better predict long term outcomes.
expertly curated content related to this topic
-
Studies of the Foregut in Patients with Familial Adenomatous Polyposis (FAP): The Clinical Problem, Management, and ...Thirty-eight published papers, co-author...
-
Medscape Overview on Familial Adenomatous PolyposisFamilial adenomatous polyposis (FAP) is ...
-
Cribriform-Morular Variant of Papillary Thyroid Carcinoma: An Indication to Screen for Occult FAPCribriform-morular variant (CMV) is a ra...
-
Germline and Somatic Mutations of the APC Gene in Papillary Thyroid Carcinoma Associated with Familial Adenomatous P...Patients with familial adenomatous polyp...
-
Pathways of Colorectal CarcinogenesisThis review of the molecular and cellula...
-
Ask the Genetic CounselorThere is colorectal cancer in my family ...
-
A Distinct Mutation on the Alternative Splice Site of APC Exon 9 Results in Attenuated Familial Adenomatous Polyposi...A subset of APC mutation carriers shows ...