Joanna L. Groden, PhD | oneFAPvoice

welcome to oneFAPvoice

- a positively charged Familial Adenomatous Polyposis community.
  • join today!

Joanna L. Groden, PhD

Department of Molecular Virology, Immunology, & Medical Genetics
Ohio State University College of Medicine
Places : Ohio State University Hospitals

Research Interests: Adenomatous Polyposis Coli, Bloom Syndrome, Colorectal Neoplasms, Colonic Neoplasms, Disease Models, Animal, Genetic Markers

The Groden Laboratory has three primary areas of interest: the study of Bloom’s syndrome, an inherited disorder that decreases chromosome stability and increases susceptibility to all types of cancer, the study of inherited disorders that increase susceptibility to colorectal cancer, especially familial adenomatous polyposis coli, and using the mouse as a model organism to learn more about how human cancers form and how we might diagnose and treat them. One aim of our laboratory is to understand the relationship between chromosome stability and neoplasia through study of the BLM helicase. BLM carries out very basic and important tasks within the cell, such as telomere elongation, resolution of stalled replication forks and responses to DNA damage. A second area of focus is to understand the genes that are altered in the development of colorectal cancer. Through study of the APC tumor suppressor and its functions in regulating the Wnt signaling pathway, we are investigating how downstream gene expression is regulated and how APC contributes to cell cycle regulation and apoptosis. Lastly, through the ability to manipulate the mouse genome, new mouse models of cancer are being developed and characterized in the laboratory. These model systems provide access to tumor material and are being used to test new ideas about the genes and their variants that affect susceptibility to cancer, as well as important environmental agents that affect tumor development.

expertly curated content related to this topic

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.