welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
The Chemopreventive Effect of Metformin in Patients With Familial Adenomatous Polyposis: Double Blinded Randomized Controlled Study
study id #: NCT01725490
condition: Familial Adenomatous Polyposis
status: recruiting
purpose:Familial adenomatous polyposis (FAP) leads to adenomas and eventual adenocarcinomas in colon and less frequently, duodenum. Chemopreventive strategies have been studied in FAP patients to delay the development of adenomas and cancers. The non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 inhibitor have shown the regression of colorectal and duodenal adenomas in FAP patients. However, these drugs showed gastrointestinal damage and cardiovascular risks, and new preventive strategies are needed. Metformin, a biguanide, which is widely used for treating diabetes mellitus, has recently been suggested to have a suppressive effect on tumorigenesis via mTOR-inhibiting pathway, and have no significant safety issues in long term use. The investigators devised a double-blind randomized controlled trial to evaluate the effect of metformin on polyps of colorectum and duodenum in non-diabetic FAP patients.
intervention: Drug: metformin
expertly curated content related to this topic
-
Diagnosis, Surveillance, and Treatment Strategies For Familial Adenomatous Polyposis: Rationale and UpdateFamilial adenomatous polyposis is charac...
-
Ostomy: Diet and Nutrition GuideThis guide provides some basic informati...
-
#jpouchFAP hashtag for the community...
-
Efficacy of pancreatic enzyme replacement therapy in chronic pancreatitis: systematic review and meta-analysisObjective The benefits of pancreatic ...
-
Chemoprevention of Colorectal Cancer: Systematic Review and Economic EvaluationBACKGROUND : Colorectal cancer (CRC) is ...
-
Rectal Epithelial Apoptosis does not Predict Response to Sulindac Treatment or Polyp Development in Presymptomatic F...Innormal colorectal epithelium, apoptosi...
-
Pharmacological and Dietary Prevention for Colorectal CancerBACKGROUND: Colorectal cancer (CRC) is ...