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Molecular Targeting of 15-Lipoxygenase-1 (15-LOX-1) for Apoptosis Induction in Human Colorectal Cancers

key information

study id #: NCT00503035

condition: Familial Adenomatous Polyposis

status: active, not recruiting

purpose:

Primary Objective: – To determine whether celecoxib downregulates GATA-6 expression to upregulate 15-LOX-1 expression and induce apoptosis in human rectal tumors, researchers will measure GATA-6 and 15-LOX-1 expression, 13-S-HODE levels, and apoptosis rates in normal and colorectal polyp epithelial tissues before and after 6 months of celecoxib treatment of patients with familial adenomatous polyposis (FAP).

intervention:
Drug: Celecoxib
Procedure: Colonoscopy Biopsy

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