welcome to oneFAPvoice- a positively charged Familial Adenomatous Polyposis community.
- join today!
Preliminary Evaluation of Septin9 in Patients With Hereditary Colon Cancer Syndromes
study id #: NCT02198092
condition: Familial Adenomatous Polyposis, Map Syndrome, Lynch Syndrome, HNPCC, Colorectal Cancer
This is an observational, case-control study evaluating the quantitative level of Septin9 in plasma pre- and post-colectomy in hereditary colorectal cancer (CRC) syndrome patients (Familial Adenomatous Polyposis (FAP), Lynch syndrome (also known as HNPCC), and Multiple Adenomatous Polyposis (MAP, also known as MYK/MYH) cases) and genetically related FAP-family members as controls and references.
intervention: Other: Epi proColon Testing
start date: July 2014
estimated completion: August 2019
last updated: August 28, 2019
size / enrollment: 24
study design: Observational Model: Case Control, Time Perspective: Prospective
- Septin9 Plasma Levels [ Time Frame: Up to 2 years ]
The primary objective of the study is the observational analysis of quantitative Septin9 plasma levels over time in hereditary CRC syndrome patients pre- and post-colectomy.
- Septin9 Plasma Levels Versus Polyps [ Time Frame: Up to 2 years ]
Correlation of quantitative Septin9 plasma levels with the approx. number of polyps
- Pre- and Post-Colectomy Colonic Epithelial Cell Numbers [ Time Frame: Up to 2 years ]
Correlation of circulating colonic epithelial cell number pre- and post-colectomy
- Septin9 Levels Versus Circulating Colonic Epithelial Cell Numbers [ Time Frame: Up to 2 years ]
Correlation of circulating colonic epithelial cell number with Septin9 levels
• Informed consent provided
• Age > or = to 18 years of age
• Patient group FAP
- Clinical diagnosis of familial adenomatous polyposis
• Patient group Lynch syndrome Clinical diagnosis of Lynch syndrome
• Patient group MAP
- Clinical diagnosis of MYH-associated polyposis and presence of more than 20 colon polyps
• Control group (FAP)
- Genetically related family member of patient
• Patients: Able and willing to attend routine follow-up as advised
• Controls, i.e. relatives of patients: Willingness to give blood at each routine follow-up as advised for the diseased relative
• Known infection with Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), or Hepatitis C Virus (HCV)
• Current diagnosis of colorectal cancer
expertly curated content related to this topic
Ursodeoxycholic Acid in the Treatment of Duodenal Adenomas in Familial Adenomatous Polyposis (FAP) PatientsMalignant transformation of adenomas of ...
Risk of Colorectal Cancer For Carriers of Mutations in MutYH, With and Without a Family History of CancerWe studied 2332 individuals with monoall...
Desmoid Update – NIH clinical trial!https://www.youtube.com/watch?v=OE_GSI8A...
Lyophilized Black Raspberries in Adults With Familial Adenomatous Polyposis (FAP)This is a 36 week dietary intervention p...
Colorectal Carcinomas, A Consideration on MutYH-Associated PolyposisColorectal cancer (CRC) is the second mo...
Biomarkers in Familial Adenomatous Polyposis: Role and SignificanceA biomarker, according to a generally ac...
Study provides better understanding of sequence of genetic events in colorectal cancer premalignancyWhole-exome sequencing of both colorecta...