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Ursodeoxycholic Acid in the Treatment of Duodenal Adenomas in Familial Adenomatous Polyposis (FAP) Patients

key information

study id #: NCT00134758

condition: Adenomatous Polyposis Coli, Familial

status: status unknown

purpose:

Malignant transformation of adenomas of the duodenum is now the leading cause of death in familial adenomatous polyposis (FAP) patients who had a restorative proctocolectomy. Ursodeoxycholic acid (UDCA) modifies the biliary acid profile and could reduce the severity of duodenal adenomas and prevent such transformation.

intervention:
Drug: Ursodeoxycholic acid
Drug: Placebo

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