Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients | oneFAPvoice

welcome to oneFAPvoice

- a positively charged Familial Adenomatous Polyposis community.
  • join today!
rareClinical
withdrawn

Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients

study id #: NCT00248053

condition: Familial Adenomatous Polyposis

status: withdrawn

purpose:

The purpose of this study is to assess if curcumin, a commonly used food spice, can regress colorectal adenomatous polyps in patients with familial adenomatous polyposis, an inherited form of colorectal cancer.

intervention: Drug: curcumin

start date: November 2005

estimated completion: June 2008

last updated: September 20, 2012

phase of development: Phase 2

study design:
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Open Label

primary outcomes:

  • polyp number and size [ Time Frame:one year ]

secondary outcomes:

  • side effects and medication compliance [ Time Frame:one year ]

inclusion criteria:

• Eligible Sexes:

- Familial adenomatous polyposis
- 18 years of age or older
- 5 or more adenomas of colorectum or ileum

exclusion criteria:
- Female patient of child bearing age not on effective birth control pills
- Pregnant women
- White blood cell (WBC) count less than 4000
- Platelets (Plts) less than 100,000
- Blood urea nitrogen (BUN) greater than 25
- Creatine greater than 1.5
- Patients unable to stop non-steroidal anti-inflammatory drugs (NSAIDs) during duration of trial
- Malignancy
- Patient with active bacterial infections of gastroesophageal reflux disease or peptic ulcer disease
- Patient on warfarin or anti-platelet drugs

sponsor: Johns Hopkins University

investigators: Francis M Giardiello, M.D.

expertly curated content related to this topic

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close