Congenital hypertrophy retinal pigment epithelium (CHRPE) is a benign lesion of the optic fundus, which typically has no clinical signifi cance. However, the recent development of CHRPE is oft en associated with familial adenomatous polyposis (FAP). Th ere are no reports of its association with a solitary colonic neoplasm. To our knowledge, we present the fi rst case of new CHRPE-like lesions as a presenta-tion of a solitary colonic pre-neoplasm. A 73-year-old woman with cataracts presented to a retina specialist for a routine eye examination. Her history consisted of surgically corrected cataracts in her left eye. She now complained of decreased vision in right eye, which had gotten progressively worse during the past 10 months, aff ecting both her near and distant vision. She con-tinued to have chronic diminished vision in her left eye. Fundoscopy revealed new, multiple lesions found in both eyes, similar to classic CHRPE lesions. Her previous fundoscopic examination 1-year earlier did not show any lesions.