Dr. Ahnen’s Research Lab

Overall research goal of Dr. Ahnen’s Research Lab is to prevent colorectal cancer (CRC). This laboratory is interested in biochemical and biologic mechanisms of the CRC chemopreventive effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and related compounds.  It is well established the populations that take NSAIDs regularly have a lower risk of colonic adenomas and cancers and NSAIDs can decrease the incidence of new adenomas and cause regression of adenomas in patients with Familial Adenomatous Polyposis.  This laboratory, in close collaboration with Dr. Pamela Rice’s laboratory, has shown that NSAIDs and related compounds induce apoptotic cell death in human adenomas (but not in normal colonic mucosa) and in colon cancer cells in culture.