welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Adrenal Incidentaloma in Familial Adenomatous Polyposis: A Long-Term Follow-Up Study and Schema for Management
source: Diseases of the colon and rectum
year: 2009
authors: O. C. C. Will, A. Hansmann, R. K. S. Phillips, F. F. Palazzo, M. Marshall, S. K. Clark, K. Meeran
summary/abstract:PURPOSE : Adrenal incidentaloma is often diagnosed in patients with familial adenomatous polyposis, because they frequently undergo abdominal imaging and have a raised incidence of adrenal incidentaloma. This study investigates the natural history of adrenal incidentaloma in familial adenomatous polyposis, and suggests a schema for management.
METHODS : An original cohort of 14 familial adenomatous polyposis patients with adrenal incidentaloma, identified prospectively 12 years ago, was followed up clinically and radiologically. A further group of 16 patients was also identified. All had lesions >1 cm. For both cohorts, characteristics of patients (genotype, age at diagnosis, concomitant diagnoses) and incidentaloma (size, laterality, rate of growth, outcome) are described.
RESULTS : Overall, 3 of 30 patients underwent adrenalectomy; one patient had pheochromocytoma and another had an adenoma of borderline malignancy. A further three lesions were radiologically suspicious for malignancy at the time of diagnosis; one was in a patient who was unfit for surgery but died of nonadrenal causes after nine years. None of the lesions radiologically benign at diagnosis showed an aggressive course, but one patient required referral for surgery after 12 years because of a slow increase in size of the lesion. There were no associations with genotype.
CONCLUSIONS : Familial adenomatous polyposis-associated adrenal incidentaloma may warrant long-term follow-up. Although the natural history is similar to lesions occurring sporadically, these patients have concomitant familial adenomatous polyposis-associated manifestations under radiologic surveillance. In this rare condition, development of a robust protocol will require evidence from worldwide patient cohorts. However, a tailored schema is suggested as a consistent basis for future modification.
organization: St. Mark's Hospital HarrowDOI: 10.1007/DCR.0b013e3181a876d6
read more full text source
expertly curated content related to this topic
-
Aggressive FibromatosisAggressive (deep or desmoid-type) fibrom...
-
Inactivation of the APC Gene is Constant in Adrenocortical Tumors from Patients with Familial Adenomatous Polyposis ...PURPOSE : In adrenocortical tumors (ACT)...
-
familial adenomatous polyposis and papillary thyroid cancerI recently saw a 35-year-old man with a ...
-
Results of a Prospective Thyroid Ultrasound Screening Program in Adenomatous Polyposis PatientsBACKGROUND: Patients with adenomatous p...
-
Familial Adenomatous Polyposis and Desmoid TumorsFamilial adenomatous polyposis (FAP) is ...
-
Therapeutic Approaches for Patients with Coexisting Familial Adenomatous Polyposis and Colorectal CancerColorectal cancer is a major cause of de...
-
Cancer Support CommunityAnyone impacted by a diagnosis of cancer...