Age- and Gender-Specific Risk of Thyroid Cancer in Patients With Familial Adenomatous Polyposis | oneFAPvoice

welcome to oneFAPvoice

- a positively charged Familial Adenomatous Polyposis community.
  • join today!
scientific articles

Age- and Gender-Specific Risk of Thyroid Cancer in Patients With Familial Adenomatous Polyposis

key information

source: The Journal of Clinical Endocrinology & Metabolism

year: 2016

authors: Uchino S, Ishikawa H, Miyauchi A, Hirokawa M, Noguchi S, Ushiama M, Yoshida T, Michikura M, Sugano K, Sakai T



The cribriform-morula variant of papillary thyroid carcinoma (CMV-PTC) is a rare variant of PTC and is associated with familial adenomatous polyposis (FAP). However, the incidence and the nature of CMV-PTC among FAP patients have not been well characterized.


The aim of this study was to determine the incidence and characteristics of thyroid cancer screened by neck ultrasonography for FAP patients. Design, Patients, and Intervention: A total of 129 FAP patients were included in this study. Neck ultrasonography was performed using a 12.0-MHz transducer probe. Germline APC gene mutation was examined for by the protein truncation test or DNA sequencing methods.


Twenty-one patients (16.3%) had solid nodules, and 24 patients (18.6%) had benign cystic nodules. In total, PTC was found in 11 patients (16% of the women and 0% of the men), 8 of which were CMV-PTC and the rest were classical PTC. In 17 female patients with thyroid nodules, CMV-PTC occurred in 8 of 9 patients who were 35 years age or younger but in none of the 8 patients who were older than 35 (P = .0004 by Fisher’s exact test). The APC germline mutations in 8 patients with CMV-PTC were present at the 5′ side of the profuse type of FAP region (codons 1249-1330).


The prevalence of CMV-PTC in FAP patients was higher than previously reported and this type of tumor was found preferentially in younger (under age 35) female patients with FAP in this cohort.

organization: Noguchi Thyroid Clinic and Hospital Foundation, Oita, Japan; Kyoto Prefectural University of Medicine, Kyoto, Japan; Ishikawa Gastrointestinal Clinic, Osaka, Japan; Kuma Hospital, Kobe, Japan; National Cancer Center Research Institute, Tokyo, Japan; Tochigi Cancer Center, Utsunomiya, Japan

DOI: 10.1210/jc.2016-2043

read more full text source

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.