APC: The Key to Colon Cancer (The APC Protein and Its Role in Controlling the Cell Cycle) | oneFAPvoice

welcome to oneFAPvoice

- a positively charged Familial Adenomatous Polyposis community.
  • join today!
abstracts & posters

APC: The Key to Colon Cancer (The APC Protein and Its Role in Controlling the Cell Cycle)

key information

source: Milwaukee School of Engineering Center for BioMolecular Modeling

year: 2010

authors: Nathan Hale High School SMART Team: Sara Baker, Chelsea Fujinaka, Melissa Gall, Laenzio Garrett, Nick Goldner, Zach Koepp, Valerie Lamphear, Peter Nguyen, Vivek Patel, Stefan Pietrzak, Evan Rypel, Ajay Sreekanth, Kyle Tretow, Tyler Zajdel


Poster Presentation

Abstract: Colorectal cancer affects 1 in 18 Americans, and is linked to mutations in the Adenomatous Polyposis Coli (APC) gene. The rapid division of colonocytes is regulated by the Wingless Type (Wnt) signaling pathway, mediated by β-catenin. In the nucleus, β- catenin binds to Transcription Cell Factor (TCF) and initiates transcription of cell cycle proteins. Alternatively, β-catenin binds to the 20-amino acid repeat region of the APC protein with the help of the scaffold axin. The enzyme GSK-3 then phosphorylates threonine and serine residues of the APC protein and subsequently β -catenin. Phosphorylated β -catenin is degraded, slowing mitosis. Mutations in APC allow β-catenin to accumulate, resulting in hyperproliferation of colonocytes, an early step in colon cancer development. As such, better understanding of APC and its function could potentially lead to better diagnosis and treatment in colorectal cancer.

organization: Nathan Hale High School

read more

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.