Assessment of Endostatin Gene Therapy for Familial Adenomatous Polyposis-related Desmoid Tumors | oneFAPvoice

welcome to oneFAPvoice

- a positively charged Familial Adenomatous Polyposis community.
  • join today!

Assessment of Endostatin Gene Therapy for Familial Adenomatous Polyposis-related Desmoid Tumors

key information

source: Cancer Research

year: 2006

authors: Martinico S C, Jezzard S, Sturt N J, Michils G, Tejpar S, Phillips RK, Vassaux G

summary/abstract:

Constitutive activation of the Wnt signaling pathway is a hallmark of many cancers, including familial adenomatous polyposis (FAP)-related desmoid tumors. Endostatin is a well-known antiangiogenic protein that has been described recently as a potential inhibitor of this signaling pathway. Here, we show that endostatin directly induces apoptosis and inhibits the Wnt signaling pathway in colorectal cancer cell lines bearing mutations on the adenomatous polyposis coli (APC) gene as a model of FAP-related malignant cells.

organization: Institute of Cancer and Cancer Research UK Clinical Centre, Barts, London Queen Mary's School of Medicine and Dentistry, London, UK

DOI: 10.1158/0008-5472.CAN-06-1209

read more full text source

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close