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Assessment of Endostatin Gene Therapy for Familial Adenomatous Polyposis-related Desmoid Tumors
source: Cancer Research
year: 2006
authors: Martinico S C, Jezzard S, Sturt N J, Michils G, Tejpar S, Phillips RK, Vassaux G
summary/abstract:Constitutive activation of the Wnt signaling pathway is a hallmark of many cancers, including familial adenomatous polyposis (FAP)-related desmoid tumors. Endostatin is a well-known antiangiogenic protein that has been described recently as a potential inhibitor of this signaling pathway. Here, we show that endostatin directly induces apoptosis and inhibits the Wnt signaling pathway in colorectal cancer cell lines bearing mutations on the adenomatous polyposis coli (APC) gene as a model of FAP-related malignant cells.
organization: Institute of Cancer and Cancer Research UK Clinical Centre, Barts, London Queen Mary's School of Medicine and Dentistry, London, UKDOI: 10.1158/0008-5472.CAN-06-1209
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