Association Between the Age and the Development of Colorectal Cancer in Patients with Familial Adenomatous Polyposis: A Multi-institutional Study. | oneFAPvoice

welcome to oneFAPvoice

- a positively charged Familial Adenomatous Polyposis community.
  • join today!
scientific articles

Association Between the Age and the Development of Colorectal Cancer in Patients with Familial Adenomatous Polyposis: A Multi-institutional Study.

key information

source: Surgery Today

year: 2016

authors: Kobayashi H, Ishida H, Ueno H, Hinoi T, Inoue Y, Ishida F, Kanemitsu Y, Konishi T, Yamaguchi T, Tomita N, Matsubara N, Watanabe T, Sugihara K

summary/abstract:

PURPOSE:

To investigate the incidence of colorectal cancer among familial adenomatous polyposis (FAP) patients by phenotype using the latest modalities.

METHODS:

We collected data on 303 patients who underwent surgery for FAP at one of 23 institutions between 2000 and 2012. The incidence of colorectal cancer was investigated by phenotype.

RESULTS:

Colorectal cancer was diagnosed in 115 (38.0 %) of the 303 patients. Overall, colorectal cancer with the attenuated, sparse, and profuse phenotypes was diagnosed at 30, 31, and 28 years of age, respectively, in 10 % of the patients and at 59, 48, and 41 years of age, respectively, in 50 % of the patients (P = 0.013). The patients with colorectal cancer were older than those without colorectal cancer for all phenotypes. The optimal cut-off age for predicting the development of colorectal cancer in the attenuated, sparse, and profuse phenotypes was 46, 31, and 27 years, respectively.

CONCLUSIONS:

Patients with profuse and sparse phenotypes should undergo prophylactic proctocolectomy before their mid-to-late 20 s. On the other hand, the timing and type of surgery for patients with attenuated FAP (AFAP) should be decided individually with reference to the colonoscopic findings.

organization: Tokyo Metropolitan Hiroo Hospital, Japanese Society for Cancer of the Colon and Rectum, Saitama Medical University, National Defense Medical College Japan, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Graduate School of Medicine Mie University, Northern Yokohama Hospital Showa University, National Cancer Center Hospital Japan, Japanese Foundation for Cancer Research, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Hyogo College of Medicine, The University of Tokyo, Tokyo Medical and Dental University

DOI: 10.1007/s00595-016-1398-1

read more full text source

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close