welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Best Practice Guidelines for Molecular Analysis of Colorectal Polyposis: Familial Adenomatous Polyposis Coli (FAP) and MutYH-Associated Polyposis (MAP)
year: 2011
authors: Fiona Macdonald, Stewart J. Payne
summary/abstract:Background:. UK Clinical Molecular Genetics Society (CMGS) consensus best practice guidelines for molecular analysis of familial adenomatous polyposis coli (FAP) were published in 2000. Technological developments in molecular testing for FAP together with the clinical and molecular characterisation of MUTYH-associated polyposis (MAP) led to the need to update the original FAP guidelines which were “retired” in December 2007. This update presents consensus best practice in the molecular analysis of clinically related colorectal polyposis syndromes of FAP and MAP. Methods: Testing and reporting guidelines have been drawn up and agreed in accordance with the procedures of the UK Clinical Molecular Genetics Society.
Results: A practical set of molecular genetic testing and reporting guidelines has been developed for both familial adenomatous polyposis coli and MUTYH-associated polyposis. In addition, advice is given on appropriate reporting policies, including advice on test sensitivity and recurrence risks. Conclusion: An agreed set of practice guidelines has been developed for the diagnostic molecular genetic testing of colorectal polyposis.
read moreexpertly curated content related to this topic
-
MUTYH Associated Polyposis (MAP)MUTYH Associated Polyposis (MAP), a Poly...
-
Bowel Cancer – How Genetic Information can Help Reduce the RiskPaul’s story about the dominantly inhe...
-
What’s New in Hereditary Colorectal Cancer?This editorial discusses practical sign...
-
Screening and Survival in Familial Adenomatous PolyposisThe key issue for all cancer screening e...
-
Screening for Colorectal Cancer: It’s the Right Choicehttps://www.fapvoice.com/wp-content/uplo...
-
Clinical and Genetic Characterization of Classical Forms of Familial Adenomatous Polyposis: A Spanish Population Stu...BACKGROUND : Classical familial adenomat...