welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Bilateral Sertoli Cell Tumors of the Testis—A Likely New Extracolonic Manifestation of Familial Adenomatous Polyposis
source: Virchows Archiv: an International journal of Pathology
year: 2012
authors: Xiao GQ, Granato RC, Unger PD
summary/abstract:Testicular Sertoli cell tumors are rare and usually sporadic and unifocal. The large cell calcifying Sertoli cell tumor variant is known to be associated with Carney and Peutz–Jeghers syndromes and can be bilateral in these patient populations. There has been no documented association of Sertoli cell tumor with familial adenomatous polyposis (FAP) in the literature. The case presented is a bilateral Sertoli cell tumor occurring in a 34-year-old patient with FAP. The tumor had a conventional Sertoli cell tumor morphology, but with different morphology in the left and right sites. Beta-catenin immunostain showed strong nuclear reactivity in the tumor cells but not the nonneoplastic Sertoli cells. The presence of bilaterality as well as overexpression of beta-catenin by this tumor supports an association of the development of Sertoli cell tumor with the patient’s FAP syndrome and adenomatous polyposis coli inactivation.
organization: Mount Sinai School of MedicineDOI: 10.1007/s00428-012-1332-x
read more full text source
expertly curated content related to this topic
-
Oral Manifestations in Patients with Familial Adenomatous Polyposis: A Systematic Review and Meta-AnalysisBACKGROUND AND AIM : The oral manifestat...
-
Adenomatous Polyposis Syndromeshttps://www.youtube.com/watch?v=pFn-A2jZ...
-
Inherited Cancer Syndromes: Current Clinical ManagementElectronic Book: The second edition of I...
-
Age- and Gender-Specific Risk of Thyroid Cancer in Patients With Familial Adenomatous PolyposisCONTEXT: The cribriform-morula variant ...
-
Small Bowel Endoscopic Evaluation in Familial Adenomatous Polyposis (FAP)Background and study aim The relative ri...
-
Early Onset of Dysplasia in Polyps in Children with Familial Adenomatous Polyposis: Case Report and Literature Revie...Familial adenomatous polyposis (FAP) is ...
-
Assessment of Endostatin Gene Therapy for Familial Adenomatous Polyposis-related Desmoid TumorsConstitutive activation of the Wnt signa...