Cancer Genetics and Prevention: MUTYH Associated Polyposis (MAP) | oneFAPvoice

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Cancer Genetics and Prevention: MUTYH Associated Polyposis (MAP)

key information

source: Dana-Farber Cancer Institute

year: 2013


MUTYH-Associated Polyposis or MAP is a genetic condition that increases one’s risk of developing gastrointestinal polyps, colorectal cancer, and to a much lesser degree, other cancers (see chart below). MAP is caused by having an alteration in each of the two copies of the MUTYH gene, one inherited from each parent. Most individuals with MAP will develop ten to a few hundred polyps by the age of 50 years. Adenomas (precancerous polyps) are the most common polyp type for individuals with MAP, however there may also be other types including hyperplastic and sessile serrated polyps. It is also possible to have MAP and develop colorectal cancer with few or no polyps. MAP is a recently described syndrome, so knowledge is still unfolding.

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