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Childbirth after Surgery for Familial Adenomatous Polyposis in Japan
source: Surgery Today
authors: Kobayashi H, Ishida H, Ueno H, Hinoi T, Inoue Y, Ishida F, Kanemitsu Y, Konishi T, Yamaguchi T, Tomita N, Matsubara N, Watanabe T, Sugihara Ksummary/abstract:
Familial adenomatous polyposis (FAP) is a genetic disorder. Some female patients with FAP can become pregnant. However, the current state of childbirth after surgery for FAP is unclear in Japan.
The study investigated 303 patients (147 female) who had undergone surgery for FAP at the 23 institutions between 2000 and 2012.
Eighty female patients had information available on childbirth after surgery for FAP. Eight patients (10 %) gave birth after surgery. The mean age at surgery for FAP was 27 (range 20-41) years and 37 years in patients with and without childbirth after surgery, respectively (P = 0.044). The rate of childbirth after surgery was 17 % in women ≤30 years of age and 13 % in those ≤40 years of age. Although only one patient with invasive cancer (2.9 %) gave childbirth after surgery, seven patients without cancer (15.6 %) gave birth (P = 0.045).
This study clarified the current state of childbirth after surgery for FAP in Japan. It is important to use these data to determine the best therapeutic approach for female FAP patients.organization: Tokyo Metropolitan Hiroo Hospital, Japanese Society for Cancer of the Colon and Rectum, Saitama Medical University, National Defense Medical College Japan, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Graduate School of Medicine Mie University, Northern Yokohama Hospital Showa University, National Cancer Center Hospital Japan, Japanese Foundation for Cancer Research, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Hyogo College of Medicine, The University of Tokyo, Tokyo Medical and Dental University
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