Cognitive Function in Familial Adenomatous Polyposis: Anyone Out There Listening? | oneFAPvoice

welcome to oneFAPvoice

- a positively charged Familial Adenomatous Polyposis community.
  • join today!
abstracts & posters

Cognitive Function in Familial Adenomatous Polyposis: Anyone Out There Listening?

key information

conference: 13th Annual Meeting of the Collaborative Group of the Americas on Inherited Colorectal Cancer

source: Hereditary Cancer in Clinical Practice

year: 2010

authors: Margaret O'Malley, Lisa LaGuardia, Richard Naugle, Cynthia Gensur, Jeff Hammel, James Church, Carol Burke


Poster Presentation

Background: Preliminary data suggests the APC protein is critical for dependent pathways in the cochlea and may be important in cognition. Abnormal audiometries have been documented in Familial Adenomatous Polyposis (FAP). We studied cognitive function among patients with FAP.

Methods: FAP patients were recruited for an IRB (Institutional Review Board) approved study assessing intelligence using the Kaufman Brief Intelligence Test (KBIT-2), which provides Verbal, Nonverbal and Composite IQs. The KBIT-2 was administered and scored by individuals experienced in administration of psychometric measures. Mean scores were analyzed and compared to standard normal ranges.

Results: 44 subjects from 42 families (22 men), mean age of 42 years were included. KBIT-2 Composite IQ score was 98.4 ± 12.4, (95% CI (confidence interval) 94.5-102.3) which is within the average range of 90-109. 27 % of patients scored below average (less than 90) and 15% scored above average (greater than 109), not a significant imbalance (sign test p=0.33). Nonverbal IQ scores show no difference from average, mean=100.5; 24% scored below and 27% scored above average. Verbal scores were 95.5 ± 12.0 (95% CI 91.7 -99.2) significantly lower than average (one-sample T-test p=0.020). There is an imbalance among patients with 27% below and 7% above the average range and a tendency toward lower than average scores (sign test P=0.06). The mean number of points by which Nonverbal IQ exceeded Verbal IQ was 5.0 ± 12.5 (95% CI 1.1 -9.0), (one-sample T-test p=0.013). The non-verbal score exceeded the verbal score for 27 patients (65.9%), while the verbal score was larger for only 10 patients (24.4%) (Sign test p=0.008).

Conclusion: Composite IQ scores suggest that FAP patients do not have lower IQ from the general population. However the verbal scores of FAP patients which are dependent on hearing are significantly lower than average and may reflect abnormal audiometries or other effects of the APC mutation on cognitive function.

organization: Cleveland Clinic

DOI: 10.1186/1897-4287-8-S1-P15

read more

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.