welcome to oneFAPvoice- a positively charged Familial Adenomatous Polyposis community.
- join today!
Colon-Specific Delivery of Celecoxib is a Potential Strategy to Improve Toxicological and Pharmacological Properties of the Selective Cox-2 Inhibitor: Implication in Treatment of Familiar Adenomatous Polyposis
source: Journal of drug targeting
authors: Yonghyun Lee, Hyunjeong Kim, Wooseong Kim, Jeong Hyun Yoon, Yunjin Jung, Seong Hoon Jeongsummary/abstract:
In general, colon-specific delivery of a drug decreases systemic absorption and increases therapeutic concentration of the drug at the target site. N-succinylglutam-1 or 5-yl celecoxib (SG1C and SG5C) were prepared as a colon-specific prodrug of celecoxib, a selective Cox-2 inhibitor, and investigated whether the celecoxib derivatives could deliver celecoxib to the target site and improve cardiovascular toxicity and therapeutic effectiveness for the treatment of familiar adenomatous polyposis. SG1C and SA5C were cleaved to release celecoxib in the cecal contents while stable in small intestinal contents. The cecal release of celecoxib was much greater for SG1C than SG5C. SG1C administered orally was barely detected in the blood and urine. SG1C delivered much greater amount of celecoxib to the large intestine while keeping the plasma concentration of celecoxib at much lower level compared with oral administration of free celecoxib. Consistent with these pharmacokinetic results, SG1C supplied a greater concentration of celecoxib for the entire colonic tissue and did not change the serum level of 6-keto-PGF(1α) whose decrease is associated with the cardiovascular toxicity of celecoxib. Taken together, colon-specific delivery of celecoxib using a prodrug approach may be a useful strategy to improve toxicological and pharmacological properties of celecoxib.organization: Pusan National University
read more full text source
expertly curated content related to this topic
In a Select Group of Patients Meeting Strict Clinical Criteria and Undergoing Ileal Pouch-Anal Anastomosis, the Omis...PURPOSE : Ileal pouch-anal anastomosis i...
Detection of Epithelial Apoptosis in Pelvic Ileal Pouches for Ulcerative Colitis and Familial Adenomatous PolyposisBACKGROUND : Ileal pouch-anal anastomosi...
Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?BACKGROUND: Duodenal polyposis is a mani...
Hereditary Colorectal Cancer Syndromes: American Society of Clinical Oncology Clinical Practice Guideline Endorsemen...Purpose: To provide recommendations on ...
Single-Incision Laparoscopic Ileal Pouch-Anal Anastomosis in Children–How Does it Compare to a Laparoscopic-As...BACKGROUND : Although single-incision la...
Bonnies Diary Dec 07https://jtvcancersupport.com/embed/28653...
Familial Adenomatous Polyposis: Challenges and Pitfalls of Surgical TreatmentSurgical management of familial adenomat...