welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Colorectal Cancer in Familial Adenomatous Polyposis: Are there Clinical Predictive Factors?
source: Cirugia espanola
year: 2010
authors: de Campos F G, Nicácio De Freitas I, Imperiale A R, Seid V E, Perez R O, Nahas S C, Cecconello I
summary/abstract:BACKGROUND : Familial Adenomatous Polyposis (FAP) is a hereditary disorder with multiple colorectal polyps that exhibit an almost inevitable risk of colorectal cancer (CRC) in untreated patients.
GOALS : To evaluate clinical features related to CRC risk at diagnosis.
MATERIAL AND METHODS : Charts from 88 patients were reviewed to collect information regarding age, family history, symptoms, polyposis severity and association with CRC.
RESULTS : 41 men (46.6%) and 47 women (53.4%) were assisted. CRC was detected in 53 patients (60.2%), with a frequency of 9.1% under 20 years, 58% between 21-40 and 85% over 41 years of age. Average age of patients without CRC was lower at treatment (29.5 vs. 40.0 years; p=0.001). Family history was reported by 58 patients (65.9%), whose average age did not differ from those who didn’t report it (33.4 vs. 34.4; p=0.17). Asymptomatic patients comprised 10.2% of the total; in this group, CRC incidence was much lower when compared to those presenting symptoms (1.1% vs. 65.8%; p=0.001). Patients without CRC presented a shorter length of symptoms (15.2 vs. 26.4 months; p=0.03) and less frequent weight loss (11.4% vs. 33.9%; p=0.01). At colonoscopy, polyposis was classified as attenuated in 12 patients (14.3%), who presented greater average age (48.2 vs. 33.3 years; p=0.02) and equal CRC incidence (58.3% vs. 58.3%; p=0.6) when compared to those with classic polyposis.
CONCLUSIONS : The risk of CRC in FAP patients 1) increases significantly after the second decade; 2) is associated with higher age, weight loss, presence and duration of simptomatology; 3) is similar in patients with attenuated or classic phenotype.
organization: Universidad de São PauloDOI: 10.1016/j.ciresp.2010.05.013
read more full text source
expertly curated content related to this topic
-
Patient Information: Colon and Rectal Cancer Screening (Beyond the Basics)Colorectal cancer develops in the large ...
-
Desmoid Tumors: Clinical Features and Treatment Options for Advanced DiseaseDesmoid tumors describe a rare monoclona...
-
Dysplastic Changes in Gastric Fundic Gland Polyps of Patients with Familial Adenomatous PolyposisBACKGROUND : Fundic gland polyps are the...
-
Risk of Thyroid Cancer Among Caribbean Hispanic Patients with Familial Adenomatous PolyposisFamilial adenomatous polyposis (FAP) is ...
-
Familial Adenomatous Polyposis – Genetics Home ReferenceFamilial Adenomatous Polyposis (FAP) is ...
-
Hereditary Colorectal CancerThis reference discusses hereditary colo...
-
Cribriform Variant Papillary Thyroid Cancer: A Characteristic of Familial Adenomatous PolyposisInherited cancer syndromes may predispos...