Colorectal Cancer in Familial Adenomatous Polyposis: Are there Clinical Predictive Factors? | oneFAPvoice

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Colorectal Cancer in Familial Adenomatous Polyposis: Are there Clinical Predictive Factors?

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source: Cirugia espanola

year: 2010

authors: de Campos F G, Nicácio De Freitas I, Imperiale A R, Seid V E, Perez R O, Nahas S C, Cecconello I


BACKGROUND : Familial Adenomatous Polyposis (FAP) is a hereditary disorder with multiple colorectal polyps that exhibit an almost inevitable risk of colorectal cancer (CRC) in untreated patients.

GOALS : To evaluate clinical features related to CRC risk at diagnosis.

MATERIAL AND METHODS : Charts from 88 patients were reviewed to collect information regarding age, family history, symptoms, polyposis severity and association with CRC.

RESULTS : 41 men (46.6%) and 47 women (53.4%) were assisted. CRC was detected in 53 patients (60.2%), with a frequency of 9.1% under 20 years, 58% between 21-40 and 85% over 41 years of age. Average age of patients without CRC was lower at treatment (29.5 vs. 40.0 years; p=0.001). Family history was reported by 58 patients (65.9%), whose average age did not differ from those who didn’t report it (33.4 vs. 34.4; p=0.17). Asymptomatic patients comprised 10.2% of the total; in this group, CRC incidence was much lower when compared to those presenting symptoms (1.1% vs. 65.8%; p=0.001). Patients without CRC presented a shorter length of symptoms (15.2 vs. 26.4 months; p=0.03) and less frequent weight loss (11.4% vs. 33.9%; p=0.01). At colonoscopy, polyposis was classified as attenuated in 12 patients (14.3%), who presented greater average age (48.2 vs. 33.3 years; p=0.02) and equal CRC incidence (58.3% vs. 58.3%; p=0.6) when compared to those with classic polyposis.

CONCLUSIONS : The risk of CRC in FAP patients 1) increases significantly after the second decade; 2) is associated with higher age, weight loss, presence and duration of simptomatology; 3) is similar in patients with attenuated or classic phenotype.

organization: Universidad de São Paulo

DOI: 10.1016/j.ciresp.2010.05.013

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