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scientific articles

Colorectal Cancers Choosing Sides

key information

source: Biochimica et Biophysica Acta

year: 2011

authors: Albuquerque C, Bakker E R, van Veelen W, Smits R

summary/abstract:

In contrast to the majority of sporadic colorectal cancer which predominantly occur in the distal colon, most mismatch repair deficient tumours arise at the proximal side. At present, these regional preferences have not been explained properly. Recently, we have screened colorectal tumours for mutations in Wnt-related genes focusing specifically on colorectal location. Combining this analysis with published data, we propose a mechanism underlying the side-related preferences of colorectal cancers, based on the specific acquired genetic defects in β-catenin signalling.

organization: Instituto Português de Oncologia de Lisboa Francisco Gentil

DOI: 10.1016/j.bbcan.2011.07.005

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