welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
scientific articles
Colorectal Cancers Choosing Sides
source: Biochimica et Biophysica Acta
year: 2011
authors: Albuquerque C, Bakker E R, van Veelen W, Smits R
summary/abstract:In contrast to the majority of sporadic colorectal cancer which predominantly occur in the distal colon, most mismatch repair deficient tumours arise at the proximal side. At present, these regional preferences have not been explained properly. Recently, we have screened colorectal tumours for mutations in Wnt-related genes focusing specifically on colorectal location. Combining this analysis with published data, we propose a mechanism underlying the side-related preferences of colorectal cancers, based on the specific acquired genetic defects in β-catenin signalling.
organization: Instituto Português de Oncologia de Lisboa Francisco GentilDOI: 10.1016/j.bbcan.2011.07.005
read more full text source
expertly curated content related to this topic
- Germline Mutations of the APC Gene in Patients with Familial Adenomatous Polyposis-Associated Thyroid Carcinoma: Res...Papillary thyroid carcinoma (PTC) is one...
- MUTYH (mutY homolog (E. coli))Review on MUTYH (mutY homolog (E. coli))...
- Clinical and Genetic Characterization of Classical Forms of Familial Adenomatous Polyposis: A Spanish Population Stu...BACKGROUND : Classical familial adenomat...
- MuTYH-Associated Colorectal Cancer and Adenomatous PolyposisMUTYH-associated polyposis (MAP) was fir...
- Location in the Large Bowel Influences the APC Mutations Observed in FAP AdenomasThe right colon differs from the left, i...
- HNPCC vs FAPhttps://www.youtube.com/watch?v=wjluqZN4...
- Hereditary Colorectal Cancer Syndromes: American Society of Clinical Oncology Clinical Practice Guideline Endorsemen...Purpose: To provide recommendations on ...
English
Portuguese
Spanish