Colorectal Carcinomas, A Consideration on MutYH-Associated Polyposis | oneFAPvoice

welcome to oneFAPvoice

- a positively charged Familial Adenomatous Polyposis community.
  • join today!
scientific articles

Colorectal Carcinomas, A Consideration on MutYH-Associated Polyposis

key information

source: Shiraz E Medical Journal

year: 2014

authors: Tayebeh Hamzehloei, Mahdieh Davoodnejad Dehsorkhi


Colorectal cancer (CRC) is the second most prevalent cancer worldwide, and in 35% of cases it is an inherited form. The most common inherited forms of CRC include; Lynch syndrome, familial adenomatous polyposis (FAP), attenuated FAP, and MUTYH-associated polyposis (MAP). Although they are inherited, they have different phenotypic effects with regards to the number of polyposis, age of onset and the pattern of inheritance. Some of these CRCs are associated with other extracolonic manifestation symptoms. MUTYH-associated polyposis (MAP) was first described in 2002. MUTYH is a component of a base excision repair system that protects the genomic information from oxidative damage. When the MUTYH gene product is impaired by bi-allelic germline mutation, it leads to the mutation of cancer-related genes, such as the APC and/or the KRAS genes, via G to T transversion. MAP is a hereditary colorectal cancer syndrome inherited in an autosomal-recessive fashion. The proposed mechanism of individual CRC is distinguished in this review paper.

organization: Mashhad University of Medical Science

DOI: 10.17795/semj21868

read more

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.