welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Colorectal Carcinomas, A Consideration on MutYH-Associated Polyposis
source: Shiraz E Medical Journal
year: 2014
authors: Tayebeh Hamzehloei, Mahdieh Davoodnejad Dehsorkhi
summary/abstract:Colorectal cancer (CRC) is the second most prevalent cancer worldwide, and in 35% of cases it is an inherited form. The most common inherited forms of CRC include; Lynch syndrome, familial adenomatous polyposis (FAP), attenuated FAP, and MUTYH-associated polyposis (MAP). Although they are inherited, they have different phenotypic effects with regards to the number of polyposis, age of onset and the pattern of inheritance. Some of these CRCs are associated with other extracolonic manifestation symptoms. MUTYH-associated polyposis (MAP) was first described in 2002. MUTYH is a component of a base excision repair system that protects the genomic information from oxidative damage. When the MUTYH gene product is impaired by bi-allelic germline mutation, it leads to the mutation of cancer-related genes, such as the APC and/or the KRAS genes, via G to T transversion. MAP is a hereditary colorectal cancer syndrome inherited in an autosomal-recessive fashion. The proposed mechanism of individual CRC is distinguished in this review paper.
organization: Mashhad University of Medical ScienceDOI: 10.17795/semj21868
read more
expertly curated content related to this topic
-
MUTYH (mutY homolog (E. coli))Review on MUTYH (mutY homolog (E. coli))...
-
Association Between the Age and the Development of Colorectal Cancer in Patients with Familial Adenomatous Polyposis...PURPOSE: To investigate the incidence o...
-
Colorectal Cancer GuidelinesThe American Society of Colon and Rectal...
-
MUTYH Gene (Protein Coding)Genetic data for MUTYH...
-
V-blog – Update!!! 2013 the year of the Desmoid!https://www.youtube.com/watch?v=HpyUTBLX...
-
Intestinal Polyposis Syndromes Clinical Presentationhttp://img.medscapestatic.com/pi/meds/ck...
-
A Germline Homozygous Loss-of-Function Mutation in the Base Excision Repair Gene NTHL1 Causes Adenomatous Polyposis ...Abstract Introduction: Patients diagn...