welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Cox-2 Polymorphisms in Patients with Familial Adenomatous Polyposis
source: Oncology research
year: 2009
authors: Wilbert H. M. Peters, Rene H. M. te Morsche, Hennie M. J. Roelofs, Elisabeth M. H. Mathus-Vliegen, Fokko M. Nagengast, Marloes Berkhout
summary/abstract:Cyclooxygenase-2 (COX-2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of biologic processes such as inflammation, cell proliferation, and angiogenesis. COX-2 has been found overexpressed in (pre)malignant tissues and may be relevant to cancer development. We investigated whether functional genetic polymorphisms in COX-2 may have a risk-modifying effect on duodenal adenomatosis in patients with familial adenomatous polyposis (FAP). Blood from 85 patients with FAP and 218 age- and sex-matched healthy subjects was investigated for the presence of two functional promoter region polymorphisms (-1195G–>A and -765G–>C) in COX-2. Logistic regression analysis revealed an overrepresentation of the -1195GG genotype compared to the -1195AA genotype in patients with FAP (odds ratio = 2.81; 95% CI = 1.00-7.91, p = 0.042). No associations between single COX-2 polymorphisms or COX-2 haplotype were found when patients were evaluated according to their Spigelman stage. The predicted low COX-2 expression genotype -1195GG was found overrepresented in the patients with FAP. The COX-2 genotypes showed no association with the severity of duodenal adenomatosis.
organization: Radboud University Nijmegen Medical Centerread more full text source
expertly curated content related to this topic
-
MUTYH (mutY homolog (E. coli))Review on MUTYH (mutY homolog (E. coli))...
-
Genotype to Phenotype: Analyzing the Effects of Inherited Mutations in Colorectal Cancer FamiliesWith improvements to DNA sequencing tech...
-
Familial Adenomatous Polyposis of the ColonFamilial adenomatous polyposis (FAP) is ...
-
Prevalence and Phenotypes of APC and MutYH Mutations in Patients with Multiple Colorectal AdenomasContext: Patients with multiple colorect...
-
A Microscopic Comparison of Normal Colonic Mucosa and that of an Adenomatous Polyp (Tubular Adenoma)http://library.med.utah.edu/WebPath/jpeg...
-
A Distinct Mutation on the Alternative Splice Site of APC Exon 9 Results in Attenuated Familial Adenomatous Polyposi...A subset of APC mutation carriers shows ...
-
Biomarkers in Familial Adenomatous Polyposis: Role and SignificanceA biomarker, according to a generally ac...
English
Portuguese
Spanish