welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Cribriform-Morular Variant of Papillary Thyroid Carcinoma
source: Pathology, research and practice
year: 2015
authors: Pradhan D, Sharma A, Mohanty S K
summary/abstract:Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare morphologic entity. This tumor is usually associated with familial adenomatous polyposis (FAP), but rarely may be sporadic. This neoplasm commonly occurs in young females. The majority of patients present with gradually enlarging painless neck mass. There is no specific imaging finding of CMV-PTC, and the diagnosis is exclusively made on pathologic examination. A multitude of cytologic features of CMV-PTC are described, which includes hypercellularity, cribriform pattern, papillary arrangement of tall columnar cells, morules, spindle cells, clear and ground-glass nuclei, hyaline material, hemosiderin-laden histiocytes, and absence of colloid in the background. CMV-PTC is histologically characterized by the papillary growth of tall columnar cells, cribriform pattern without colloid, spindle cells, squamoid morules, and nuclear clearing. The immunoreactivity for beta-catenin and biotin-positive nuclear clearing may indicate CMV-PTC. Total thyroidectomy for familial or lobectomy for sporadic cases is usually the treatment for CMV-PTC. It carries a better prognosis than the other aggressive variants of papillary thyroid carcinoma. In this review, we discuss the current knowledge on CMV-PTC and its clinical relevance.
organization: Medicine Core Diagnostics, University of Pittsburgh Medical CenterDOI: 10.1016/j.prp.2015.04.011
read more full text source
expertly curated content related to this topic
-
Gene Variants Associated to Malignant Thyroid Disease in Familial Adenomatous Polyposis: A Novel APC Germline Mutati...BACKGROUND AND AIM : Familial adenomatou...
-
Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?BACKGROUND: Duodenal polyposis is a mani...
-
Our Experience of Treatment of Cribriform Morular Variant of Papillary Thyroid Carcinoma; Difference in Clinicopatho...Cribriform-morular variant (CMV) is a co...
-
Familial Adenomatous Polyposis by Douglas Riegert-Johnson, Physician at Mayo Clinichttp://www.slideshare.net/douglasriegert...
-
Cancer Prevention Pharmaceuticals in Collaboration with the NCI and Vanderbilt University Medical Center Initiates P...Cancer Prevention Pharmaceuticals, Inc. ...
-
Screening and Surveillance of the Early Detection of Colorectal Cancer and Adenomatous PolypsIn the United States, colorectal cancer ...
-
Jejunal Cancer in Patients With Familial Adenomatous PolyposisBACKGROUND & AIMS: Familial adenoma...