welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Cribriform Variant Papillary Thyroid Cancer: A Characteristic of Familial Adenomatous Polyposis
source: Thyroid
year: 2001
authors: Fenton P A, Clarke S E, Owen W, Hibbert J, Hodgson S V
summary/abstract:Inherited cancer syndromes may predispose to more than one type of cancer, and these characteristically develop at an earlier age than their sporadic counterparts. The occurrence in a single individual of multiple, early onset primary cancers may indicate an inherited cancer susceptibility. Familial adenomatous polyposis (FAP), an autosomal, dominantly inherited susceptibility to colorectal adenomas and cancer also predisposes to childhood medulloblastomas and to a specific rare histologic type (cribriform variant) of papillary thyroid cancer. We describe a patient who developed a childhood medulloblastoma of the cerebellum, and subsequently a cribriform papillary thyroid cancer. These cancers predated the diagnosis of FAP in this patient, who was later found to have several relatives with FAP. The adenomatous polyposis coli (APC) mutation delineated in this family was in the region associated with those causing an increased risk of thyroid cancer. We submit that the diagnosis of the cribriform variant of papillary thyroid cancer in a young individual, especially after a previous cancer diagnosis, should alert the physician to the possibility of a diagnosis of FAP.
organization: St. Thomas' School of Medicineread more full text source
expertly curated content related to this topic
-
Familial Nonmedullary Thyroid Cancer: Screening, Clinical, Molecular and Genetic FindingsThyroid cancer, the commonest of endocri...
-
Familial Adenomatous Polyposis with Synchronous Invasive Colonic Carcinomas and Metastatic Jejunal Adenocarcinoma in...Familial adenomatous polyposis is rare. ...
-
Multiple Desmoid Tumors in a Patient with Familial Adenomatous Polyposis caused by the Novel W421X MutationFamilial adenomatous polyposis (FAP) is ...
-
Low-Dose Dacarbazine-Doxorubicin Therapy Against Intra-Abdominal Desmoid TumorsIntra-abdominal desmoid tumor is a life-...
-
A de novo Desmoid Tumor of the Surgical Site Following Foramen Magnum Meningioma Resection in a Patient with Gardner...BACKGROUND : Gardner's Syndrome is a fam...
-
Inactivation of the APC Gene is Constant in Adrenocortical Tumors from Patients with Familial Adenomatous Polyposis ...PURPOSE : In adrenocortical tumors (ACT)...
-
Is There a Relationship Between Familial Adenomatous Polyposis and Focal Nodular Hyperplasia?Focal nodular hyperplasia (FNH) is the s...