welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Dacarbazine-Doxorubicin Therapy Ameliorated an Extremely Aggressive Mesenteric Desmoid Tumor Associated with Familial Adenomatous Polyposis: Report of a Case
source: Japanese journal of clinical oncology
year: 2008
authors: Koji Ezumi, Hirofumi Yamamoto, Ichiro Takemasa, Masaya Nomura, Mitsugu Sekimoto, Morito Monden, Masataka Ikeda
summary/abstract:A 30-year-old man with familial adenomatous polyposis (FAP) underwent prophylactic proctocolectomy by laparoscopy-assisted surgery. After 10 months, we found an intra-abdominal tumor, which grew rapidly to 25 cm in diameter. We performed an emergency operation, which revealed that it was a desmoid tumor derived mainly from colorectal mesenterium. The tumor was removed with three short segments of intestine and the left ureter. A computed tomography (CT) scan done 3 months later showed a 10 cm mesenteric desmoid tumor at the beginning of jejunum, approaching the root of the superior mesenteric artery (SMA). Fortunately, we were able to remove the tumor without injuring the SMA. To our distress, however, another recurrent mesenteric desmoid tumor was discovered in the pelvis one month later, which grew rapidly from 5 cm to 16 cm within 4 months. During this period, we gave the patient several regimens, including antiestrogen (tamoxifen), a nonsteroidal anti-inflammtory drug and imatinib mesylate (Gleevec), which had little or no effect. Finally, when the desmoid occupied the pelvic space, we gave the patient dacarbazine (DTIC) and doxorubicin (DOX). After seven courses, the mesenteric tumor showed an almost complete response (CR). The chemotherapy caused grade 3 to 4 leukocytopenia, but without any hazardous events. No evidence of further recurrence of mesenteric desmoid has been seen for 4 years. This combination chemotherapy is a promising strategy, even against an extremely aggressive, life-threatening mesenteric desmoid associated with FAP.
organization: Osaka UniversityDOI: 10.1093/jjco/hyn004
read more full text source
expertly curated content related to this topic
- Familial Adenomatous Polyposis; 30-Year Observation of a Female Patient – Case ReportFamilial Adenomatous Polyposis (FAP) is ...
- A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner SyndromeThe purpose of this study is to assess t...
- AJR Teaching File: Brain Tumor in a Patient with Familial Adenomatous PolyposisClinical HistoryA 25-year-old woman ...
- Shrinking the silenceI’ve been thinking about starting a bl...
- Colorectal Cancer GuidelinesThe American Society of Colon and Rectal...
- The Skin and FAPhttp://image.slidesharecdn.com/versionbp...
- The Association Between Home Parenteral Nutrition and Patients with FAP-Associated Intra-abdominal Desmoids: A Retro...BACKGROUND: Intra-abdominal desmoid tum...