welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Descriptive Review and Comparison of Clinical Outcomes of AFAP Patients
source: Hereditary Cancer in Clinical Practice
year: 2011
authors: Heidi McCoy, Wendy Kohlmann, Deborah W. Nellason, Randall W. Burt, Ken M. Boucher
summary/abstract:Poster Presentation
Objective: This study aims to examine colonic polyp phenotype, the surgical outcomes, and the reasons for colectomy in individuals with attenuated familial adenomatous polyposis (AFAP).
Methods: Colonoscopy and colectomy medical records were obtained for 197 individuals with a known genetic mutation in the region of the APC gene causative of AFAP.
Results: The number of adenomas was highly variable for both individuals being screened by colonoscopy and those having had a colectomy. The probability of an AFAP patient in this cohort having a colectomy is only 20% at age 40, however, after this age, the probability climbs dramatically. The average age of colectomy is 52 years. By age 70, the cumulative probability of having a colectomy is approximately 80% in this AFAP population. When the population was broken into 5 equal sized birth cohorts (Figure1), we see a trend whereby colectomies are being performed at younger ages in the most recent cohorts (p=0.0001). The major reason for colectomy is a high number or polyps (Figure 1).
Discussion: Colectomy appears to becoming more common in patients with AFAP and is being recommended at younger ages. A greater number of colectomies were performed in the 1990s which coincided with the identification of the APC gene mutation in this family. Subtotal colectomy with ileorectal anastomosis (IRA) is the most common type of colectomy, though 23% still had proctocolectomies with ileoanal anastomosis. Cancer risk did not necessarily correlate with polyp number as 7 individuals with fewer than 20 polyps developed cancer. In the end several factors should be considered in developing a management plan for individuals with AFAP, including lifestyle, polyp number, comorbidities, adherence to screening and patient attitudes.
organization: University of UtahDOI: 10.1186/1897-4287-9-S1-P25
read more
expertly curated content related to this topic
-
High-Dose Tamoxifen and Sulindac as First-Line Treatment for Desmoid TumorsBACKGROUND : Desmoid tumors are mesenchy...
-
Phase I Trial of Exisulind (Sulindac Sulfone, FGN-1) as a Chemopreventive Agent in Patients with Familial Adenomatou...Exisulind (sulindac sulfone; FGN-1), a m...
-
Significantly Increased Pregnancy Rates After Laparoscopic Restorative Proctocolectomy: A Cross-sectional StudyOBJECTIVE: To assess the impact of a la...
-
Victoria’s OTHER Secret: Designer Creates World’s first Lingerie Colostomy Bags as They often Put Partners OffA young designer has taken fashion into ...
-
Chemoprevention of Colorectal Cancer: Systematic Review and Economic EvaluationBACKGROUND : Colorectal cancer (CRC) is ...
-
Erlotinib Hydrochloride in Reducing Duodenal Polyp Burden in Patients With Familial Adenomatous Polyposis at Risk of...This phase II trial studies the side eff...
-
Cancer Prevention Pharmaceuticals, Inc. and Tillotts Pharma AG Sign Licensing Agreement for CPP-1X/sulindac in Europ...Cancer Prevention Pharmaceuticals, Inc. ...