source: Journal of biophotonics

year: 2011

authors: Ali Basiri, Daniel L. Edelstein, Jenna Graham, Afshin Nabili, Jessica C. Ramella-Roman, Francis M. Giardiello

Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. We investigated a novel spectro-polarimetric imaging system capable of capturing high-resolution images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Results of a clinical trial show that the system is capable of separating FAP positive individuals from controls by measuring the individuals’ oral vascular density and complexity.