welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Endoscopic Management of Familial Adenomatous Polyposis in Patients Refusing Colectomy
source: Endoscopy
year: 2015
authors: Ishikawa H, Mutoh M, Iwama T, Suzuki S, Abe T, Takeuchi Y, Nakamura T, Ezoe Y, Fujii G, Wakabayashi K, Nakajima T, Sakai T
summary/abstract:BACKGROUND AND STUDY AIMS : Colectomy protects against colorectal cancer in familial adenomatous polyposis (FAP); however, some patients with FAP refuse surgery. The aim of this study was to evaluate the feasibility and safety of endoscopic management of these patients.
PATIENTS AND METHODS : A retrospective review of medical records was performed to identify adult patients with FAP who refused colectomy and were managed by repeated colonoscopies to remove numerous polyps between 2001 and 2012. Polyps were removed by hot snare polypectomy or endoscopic mucosal resection. Polyps of < 10 mm in size and without endoscopic features suggesting cancer were discarded without histological examination; the remaining polyps were examined histologically.
RESULTS : Of the 95 eligible patients, five (5.3 %) were excluded. The remaining 90 patients (median age at first visit 29 years [range 16 - 68 years]; 46 males) were followed for a median of 5.1 years (interquartile range [IQR] 3.3 - 7.3 years). During this period, a total of 55 701 polyps were resected without adverse events such as bleeding or perforation. The median numbers of endoscopic treatment sessions and polyps removed per patient were 8 (IQR 6 - 11) and 475 (IQR 211 - 945), respectively. Five patients had noninvasive carcinoma (Category 4.2 according to the revised Vienna classification), detected within 10 months from the start of the follow-up period. All of these patients were treated endoscopically, without signs of recurrence during a median follow-up of 4.3 years (IQR 2.0 - 7.1 years). No invasive colorectal cancer was recorded during the study period. Two patients (2.2 %) underwent colectomy because the polyposis phenotype had changed to dense polyposis.
CONCLUSION : Endoscopic management of FAP is feasible and safe in the medium term.
organization: Kyoto Prefectural University of Medicine, National Cancer Center Research Institute, Saitama Medical University, Nagoya University Graduate School of Medical Sciences, Takarazuka Municipal Hospital, Osaka Medical Center for Cancer and Cardiovascular Diseases, Ryukoku University, Kyoto University, University of ShizuokaDOI: 10.1055/s-0034-1392774
read more full text source
expertly curated content related to this topic
-
Intestinal Pouch Complications in Patients who Underwent Restorative Proctocolectomy for Ulcerative Colitis and Fami...UNLABELLED : Restorative proctocolectomy...
-
SCALEing F.A.P.: Impact of J-Pouch Surgeries on My Weighthttps://www.youtube.com/watch?v=Nz2p-KzD...
-
Shattering Cancer with Resonant Frequencies: Anthony Holland at TEDx Skidmore Collegehttps://www.youtube.com/watch?v=1w0_kazb...
-
Bonnies Diary Nov 07https://jtvcancersupport.com/embed/26653...
-
Two Cases of Multiple Adenomas in the Ileal Pouch After Total Proctocolectomy in Patients with Familial Adenomatous ...Familial adenomatous polyposis (FAP) is ...
-
Chemoprevention of Colorectal CancerColorectal cancer has become one of the ...
-
Primary and Secondary Restorative Proctocolectomy for Familial Adenomatous Polyposis: Complications and Long-Term Bo...AIM : The aim of the study was to evalua...