source: Annals of Oncology
H. J. Schmoll, E. Van Cutsem, A. Stein, V. Valentini, B. Glimelius, K. Haustermans, B. Nordlinger, C. J. van de Velde, J. Balmana, J. Regula, I. D. Nagtegaal, R. G. Beets-Tan, D. Arnold, F. Ciardiello, P. Hoff, D. Kerr, C. H. Köhne, R. Labianca, T. Price, W. Scheithauer, A. Sobrero, J. Tabernero, D. Aderka, S. Barroso, G. Bodoky, J. Y. Douillard, H. E. Ghazaly, J. Gallardo, A. Garin, R. Glynne-Jones, K. Jordan, A. Meshcheryakov, D. Papamichail, P. Pfeiffer, I. Souglakos, S. Turhal, A. Cervantes
Colorectal Cancer (CRC) is the most common tumour type in both sexes combined in Western countries. Although screening programmes including the implementation of faecal occult blood test and colonoscopy might be able to reduce mortality by removing precursor lesions and by making diagnosis at an earlier stage, the burden of disease and mortality is still high. Improvement of diagnostic and treatment options increased staging accuracy, functional outcome for early stages as well as survival. Although high quality surgery is still the mainstay of curative treatment, the management of CRC must be a multi-modal approach performed by an experienced multi-disciplinary expert team. Optimal choice of the individual treatment modality according to disease localization and extent, tumour biology and patient factors is able to maintain quality of life, enables long-term survival and even cure in selected patients by a combination of chemotherapy and surgery. Treatment decisions must be based on the available evidence, which has been the basis for this consensus conference-based guideline delivering a clear proposal for diagnostic and treatment measures in each stage of rectal and colon cancer and the individual clinical situations. This ESMO guideline is recommended to be used as the basis for treatment and management decisions.
Martin Luther University Halle, University Hospital Gasthuisberg, University Comprehensive Cancer Center Hamburg-Eppendorf, Policlinico Universitario, Uppsala University, Karolinska Institutet Stockholm, University Hospitals Leuven Campus Gasthuisberg, Assistance-Publique-Hôpitaux de Paris, Université Versailles Saint Quentin en Yvelines, Leiden University Medical Center, University Hospital Vall d'Hebron, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Radboud University Nijmegen Medical Center, University Hospital of Maastricht, Second University of Naples, Universidade de São Paulo, University of Oxford, Ospedali Riuniti Bergamo, The Queen Elizabeth Hospital of Woodville, Medical University of Vienna, Oncologia Medica Ospedale S. Martino, Universitat Autònoma de Barcelona, Sheba Medical Center, Hospital do Espirito Santo de Evora, St. László Teaching Hospital of Budapest, Institut de Cancérologie de l'Ouest–René Gauducheau, Ain Shams University, Clínica Alemana INTOP, N. N. Blokhin Russian Cancer Research Center, Mount Vernon Hospital, Bank of Cyprus Oncology Centre, Odense University Hospital, University of Crete, Marmara University Hospital of Istanbul, University of Valencia