Extracolonic Manifestations of Hereditary Colorectal Cancer Syndromes | oneFAPvoice

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Extracolonic Manifestations of Hereditary Colorectal Cancer Syndromes

key information

source: Clinics in colon and rectal surgery

year: 2008

authors: Daniel A. Anaya, George J. Chang, Miguel A. Rodriguez-Bigas

summary/abstract:

Familial colorectal adenocarcinoma (CRC) accounts for approximately 15 to 20% of CRC. Of these, hereditary nonpolyposis colorectal cancer (HNPCC) and familial adenomatous polyposis (FAP) represent the most common hereditary syndromes associated with CRC, followed by other less common diseases including juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS). Extracolonic manifestations are common in each of these syndromes having significant implications for surveillance and management in at-risk individuals. The authors review the most common and clinically relevant extracolonic manifestations for each of these syndromes focusing on incidence, presentation, genotype/phenotype correlations, and management (including surveillance) strategies.

organization: The University of Texas M D Anderson Cancer Center

DOI: 10.1055/s-0028-1089941

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