welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Familial Adenomatous Polyposis in Three Generations of a Single Family: A Case Study
source: Case reports in oncology
year: 2014
authors: Murgic J, Kirac I, Soldic Z, Tomas D, Zovak M, Bolanca A, Plawski A, Banasiewicz Y, Kusic Z
summary/abstract:BACKGROUND : Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited syndrome characterized by the development of numerous polyps in the colon and rectum. If left untreated, the affected patients inevitably develop colon cancer by the age of 40 years. A resection of the colon (colectomy) or of the colon and rectum (proctocolectomy) is needed to minimize the risk of cancer.
CASE PRESENTATION : We report a case of FAP through three generations of a single family, in which the grandmother and granddaughter underwent total colectomy with ileoanal anastomosis and did not develop colon cancer, while the son underwent subtotal colectomy with ileorectal anastomosis and developed recurrent rectal cancer. Data regarding timely surgery, surveillance, and chemoprevention are discussed.
CONCLUSION : The FAP phenotype determines the type of treatment. In severe polyposis, proctocolectomy with ileoanal anastomosis seems to be the optimal method for minimizing the risk of cancer development. This case report advocates complete rectal removal, especially in cases of poor patient compliance with colonoscopic surveillance.
organisation: Croatia University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Poznań University of Medical SciencesDOI: 10.1159/000363221
abstract source full text source
rareRelated
expertly curated content related to this topic
-
Bowel Cancer – How Genetic Information can Help Reduce the RiskPaul’s story about the dominantly inhe...
-
Familial adenomatous polyposis (FAP) is ...
-
Adenomatous polyps are found on screenin...
-
Summary description of familial adenomat...