welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Familial Nonmedullary Thyroid Cancer: Screening, Clinical, Molecular and Genetic Findings
source: Biochimica et biophysica acta
year: 2014
authors: Navas-Carrillo D, Ríos A, Rodríguez J M, Parrilla P, Orenes-Piñero E
summary/abstract:Thyroid cancer, the commonest of endocrine malignancies, continues increasing in incidence being the 5th more prevalent cancer among women in the United States in 2012. Familial thyroid cancer has become a well-recognized, unique, clinical entity in patients with thyroid cancer originating from follicular cells, that is, nonmedullary thyroid carcinoma. Hereditary nonmedullary thyroid cancer may occur as a minor component of familial cancer syndromes (familial adenomatous polyposis, Gardner’s syndrome, Cowden’s disease, Carney’s complex type 1, Werner’s syndrome, and papillary renal neoplasia) or as a primary feature (familial nonmedullary thyroid cancer [FNMTC]). Although there is some controversy, some epidemiologic and clinical kindred studies have shown that FNMTC is associated with more aggressive disease than sporadic cases, with higher rates of multicentric tumours, lymph node metastasis, extrathyroidal invasion, and shorter disease-free survival. This way, preventing screening will allow earlier detection, more timely intervention, and hopefully improved outcomes for patients and their families. On the other hand, in the last years, an important number of genetic studies on FNMTC have been published, trying to determine its genetic contribution. However, the genetic inheritance of FNMTC remains unclear; but it is believed to be autosomal dominant with incomplete penetrance and variable expressivity. This paper provides an extensive overview of FNMTC from several points of view. Firstly, the impact of early detection on prognosis, secondly, the management and follow-up of FNMTC patients, and finally, the role of susceptibility loci, microRNAs (miRNAs) and telomerases in recently identified isolated cases of FNMTC.
organization: University of MurciaDOI: 10.1016/j.bbcan.2014.09.002
read more full text source
expertly curated content related to this topic
-
Management of Duodenal Adenomatosis in FAP: Single Centre ExperienceDuodenal and ampullary carcinoma in fami...
-
Jejunal Cancer in Patients With Familial Adenomatous PolyposisBACKGROUND & AIMS: Familial adenoma...
-
Long-Term Outcome of Sporadic and FAP-Associated Desmoid Tumors Treated with High-Dose Selective Estrogen Receptor M...Aim of this study is to evaluate the out...
-
Desmoid Tumors: Clinical Features and Treatment Options for Advanced DiseaseDesmoid tumors describe a rare monoclona...
-
Cribriform-Morular Variant of Papillary Thyroid Carcinoma: Clue to Early Detection of Familial Adenomatous Polyposis...The cribriform-morular variant (CMV) of ...
-
Rare Case of Intraintestinal Stromal Tumors in the Patient with Familial Adenomatous PolyposisAIM : To describe the case of metachrono...