source: Leiden University Medical Center
authors: MH Nieuwenhuis, KFL Douma, EMA Bleiker, WA Bemelman, NK Aaronson, HFA Vasen summary/abstract:
Background & Aims: Most familial adenomatous polyposis (FAP) patients have a prophylactic colectomy before age 30.
In ulcerative colitis patients, reduced fertility is observed more frequently after a proctocolectomy with ileoanal pouch anastomosis (IPAA), compared to an ileorectal anastomosis (IRA) procedure.
Few studies focused on fertility problems in FAP patients.
Aims of this study:
• To describe postoperative fertility problems in female FAP patients
• To investigate the association between self-reported fertility problems and surgery-related factors.
Methods: A questionnaire addressing sociodemographic, clinical and psychosocial issues was sent to FAP patients and their relatives, registered at the Dutch Polyposis Registry.
Inclusion criteria: women with an established diagnosis of FAP, who had undergone colectomy.
Specific questions included type and number of surgical procedures, whether or not fertility problems due to surgery for FAP had been experienced, and the actual desire for children.
Summary & Conclusions: 17% of female FAP patients reported fertility problems due to colectomy.
Fertility problems occurred evenly after IRA, IPAA and colectomy with ileostomy.
No association between surgery-related factors (indication for surgery, number of operations and number of procedures with complications) or FAP-related factors (desmoid tumors, cancer, other co-morbidity) and self-reported fertility problems.
More postoperative fertility problems among women who had a diagnosis of FAP and the first surgical procedure at a young age.
The Netherlands Foundation for Detection of Hereditary Tumors, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Academic Medical Center Amsterdam, Leiden University Medical Center read more