welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Gardner Syndrome: Skin Manifestations, Differential Diagnosis and Management
source: American journal of clinical dermatology
year: 2010
authors: Juhn E, Khachemoune A
summary/abstract:Gardner syndrome is a variant of familial adenomatous polyposis (FAP) and results in the manifestation of numerous external and internal symptoms including gastrointestinal polyps, osteomas, tumors, and epidermoid cysts. As such, it is highly recommended that physicians conduct full body examinations to catch the key clinical features of the disease when it is suspected. Stemming from a mutation in the adenomatous polyposis coli (APC) gene, Gardner syndrome shares genetic correlations with the FAP phenotype; as a result, it becomes all the more crucial for physicians to be able to discern Gardner syndrome from other differential diagnoses such as Turcot syndrome, FAP, and other attenuated forms of familial polyposis. Fortunately, Gardner syndrome has characteristic polyps in the colon, osteomas, and also exhibits abnormalities in the retinal epithelium that discern it from others. Surgery is the most effective method of management for Gardner syndrome; restorative proctocolectomy with ileal pouch anal anastomosis with mucosectomy is the top choice for colonic malignancies, and skin manifestations can be treated through a variety of excisions and therapy depending on location, size, and number of malignancies. Currently, there are no specific screening recommendations for Gardner syndrome, but testing following general screening recommendations for extra-colonic malignancies, genetic counseling, and endoscopy are encouraged.
organization: Resident PG2 Internal MedicineDOI: 10.2165/11311180-000000000-00000
read more full text source
expertly curated content related to this topic
-
Familial Adenomatous Polyposis by Douglas Riegert Johnsonhttp://www.slideshare.net/douglasriegert...
-
Practical guide to exocrine pancreatic insufficiency – Breaking the mythsBACKGROUND: Exocrine pancreatic insuf...
-
OncoGenetic Testing for Lynch Syndrome and Familial Adenomatous PolyposisThis clinical practice guideline is base...
-
Role of the Microenvironment in the Tumourigenesis of Microsatellite Unstable and MutYH-Associated Polyposis Colorec...Two forms of genomic instability can be ...
-
Clinical Management of Adenomatous Polyposis in Patients with Hereditary Non-Polyposis Colorectal Cancer and Familia...OBJECTIVE : To investigate the validity ...
-
What are ostomies?https://www.youtube.com/watch?v=VIms6TbN...