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scientific articles

Genetic Counseling and Prognosis of the Development of Complications in Patients with Syndromes of Hereditary Polyposis of the Colon

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source: Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukrainy

year: 2010

authors: Lozyns'ka M R, Hnateĭko O Z, Hel'ner N V, Pretsel' O O, Lozyn'ska Liu


Physical examinations, genealogic analysis and genetic consulting were done for 14 probands and their family members with most frequent syndromes of hereditary polyposis of large bowel during 4 generations. These syndromes include familial adenomatous polyposis, Gardner syndrome and Peutz-Jeghers syndrome. 46 relatives of probands with the same pathology were affected (from 1 to 9 of affected relatives within families). We have found the congenital abnormalities in 13 (28.2%) patients with syndromes of hereditary polyposis. 29 (63%) patients have malignant neoplasia. In families with high risk for hereditary polyposis we recommend regular medical and genetic consultation for early prophylaxis of illness and for genetic risk of possible complications in their members.

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