welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Hepatocelluar Carcinoma Associated with Attenuated Familial Adenomatous Polyposis: A Case Report and Review of the Literature
source: Clinical Colorectal Cancer
year: 2012
authors: Li M, Gerber D A, Koruda M, O'Neil B H
summary/abstract:Hepatocelluar carcinoma (HCC) has rarely been associated with familial adenomatosis polyposis (FAP). Between 1950 and 2011, only a few cases of HCC associated with classic FAP have been reported in the medical literature. Here, we report the first case to our knowledge of HCC associated with attenuated FAP (aFAP). The patient possessed a single nucleotide mutation in the noncoding region after exon 4, which is rarely observed in attenuated FAP, and not previously reported in classic FAP–associated HCC. Our patient underwent liver transplantation for a 22-cm-large HCC (in China), however, her HCC recurred 1.5 years after the transplantation. Here we review the medical literature on FAP and HCC, with a particular focus on the role of the Wnt/APC/β-catenin pathway toward a better understanding of HCC pathogenesis.
organization: University of North Carolina at Chapel HillDOI: 10.1016/j.clcc.2011.05.007
read more full text source
expertly curated content related to this topic
-
Annual DTRF Patient Meeting**BIG NEWS: The DTRF September weekend i...
-
Familial Adenomatous Polyposis-Associated Papillary Thyroid CancerPapillary thyroid carcinoma (PTC) associ...
-
Protein-losing enteropathy in a patient with familial adenomatous polyposis and advanced colon cancerAbstract A 29-year-old female visited...
-
The Proper Diagnostic Pathway of Gardner’s Syndrome: Role of the Dentist in the Early Detection of the Associated ...Gardner’s syndrome is a genetic diseas...
-
Assessment of Endostatin Gene Therapy for Familial Adenomatous Polyposis-related Desmoid TumorsConstitutive activation of the Wnt signa...
-
Familial Adenomatous Polyposis (FAP) in 9 Hispanic WomenPoster Presentation Background: Famil...
-
Carcinoma Colon and Managementhttp://www.slideshare.net/shivkishor/car...