Hepatocelluar Carcinoma Associated with Attenuated Familial Adenomatous Polyposis: A Case Report and Review of the Literature | oneFAPvoice

welcome to oneFAPvoice

- a positively charged Familial Adenomatous Polyposis community.
  • join today!
scientific articles

Hepatocelluar Carcinoma Associated with Attenuated Familial Adenomatous Polyposis: A Case Report and Review of the Literature

key information

source: Clinical Colorectal Cancer

year: 2012

authors: Li M, Gerber D A, Koruda M, O'Neil B H

summary/abstract:

Hepatocelluar carcinoma (HCC) has rarely been associated with familial adenomatosis polyposis (FAP). Between 1950 and 2011, only a few cases of HCC associated with classic FAP have been reported in the medical literature. Here, we report the first case to our knowledge of HCC associated with attenuated FAP (aFAP). The patient possessed a single nucleotide mutation in the noncoding region after exon 4, which is rarely observed in attenuated FAP, and not previously reported in classic FAP–associated HCC. Our patient underwent liver transplantation for a 22-cm-large HCC (in China), however, her HCC recurred 1.5 years after the transplantation. Here we review the medical literature on FAP and HCC, with a particular focus on the role of the Wnt/APC/β-catenin pathway toward a better understanding of HCC pathogenesis.

organization: University of North Carolina at Chapel Hill

DOI: 10.1016/j.clcc.2011.05.007

read more full text source

expertly curated content related to this topic

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close