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scientific articles

Hereditary and Common Familial Colorectal Cancer: Evidence for Colorectal Screening

key information

source: Digestive diseases and sciences

year: 2015

authors: Samadder N J, Jasperson K, Burt R W

summary/abstract:

Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30% of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines.

organization: University of Utah

DOI: 10.1007/s10620-014-3465-z

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