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scientific articles
Hereditary Colorectal Cancer Syndromes and Genetic Testing
source: Journal of surgical oncology
year: 2015
authors: Macaron C, Leach B H, Burke C A
summary/abstract:Colorectal cancer (CRC) is a leading cause of cancer and cancer deaths in the Western world. Approximately 5-10% of CRC are hereditary, due to a defined genetic cause. Individuals and families affected with a hereditary CRC syndrome exhibit benign and malignant extra-intestinal tumors, require aggressive cancer screening and benefit from management by a multi-disciplinary team of professionals. The clinical manifestations, genetic causes and current management of patients with hereditary colon cancer syndrome is provided.
organization: The Cleveland ClinicDOI: 10.1002/jso.23706
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