welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Jejunal Cancer in Patients With Familial Adenomatous Polyposis
source: Clinical gastroenterology and hepatology
year: 2010
authors: Ruys A T, Alderlieste Y A, Gouma D J, Dekker E, Mathus-Vliegen E M
summary/abstract:BACKGROUND & AIMS:
Familial adenomatous polyposis (FAP) is an inherited disease affecting approximately 1:10,000 newborns, characterized by the formation of numerous adenomas in the digestive tract. Surveillance and prophylactic treatment of colonic and duodenal manifestations of this disease have much influenced disease course and survival. In more recent years, it has become clear that adenoma formation in FAP patients is not restricted to the colon and duodenum. Accordingly, these adenomas might have malignant potential, although the actual risk is unknown.
METHODS:
We report 3 cases of jejunal carcinoma in FAP patients and review data on incidence, prognosis, and risk factors of jejunoileal adenoma and carcinoma development in FAP.
RESULTS:
Three patients with FAP aged 71, 57, and 59 years developed advanced duodenal adenomatosis and a jejunal carcinoma, which was associated with poor prognosis in 2 patients.
CONCLUSIONS:
Jejunal adenomas in FAP patients are reported occasionally and can progress into adenocarcinoma with a poor prognosis. In the future a subset of FAP patients benefitting from jejunal surveillance should be identified.
DOI: 10.1016/j.cgh.2010.04.008
read more full text source
expertly curated content related to this topic
-
Familial Adenomatous Polyposis and Other Polyposis SyndromesThis book discusses Familial Adenomatou...
-
The Association Between Home Parenteral Nutrition and Patients with FAP-Associated Intra-abdominal Desmoids: A Retro...BACKGROUND: Intra-abdominal desmoid tum...
-
The Role of High-resolution Endoscopy and Narrow-Band Imaging in the Evaluation of Upper GI Neoplasia in Familial Ad...BACKGROUND: The Spigelman classificatio...
-
Familial Adenomatous Polyposis-Associated Papillary Thyroid CancerPapillary thyroid carcinoma (PTC) associ...
-
Successful Treatment of Ileal Pouch Desmoids using Multimodal Chemotherapy with Low-Dose Vinblastine and Methotrexat...We describe a case of multiple desmoid t...
-
Genotype and Phenotype of Patients with Both Familial Adenomatous Polyposis and Thyroid CarcinomaThe incidence of thyroid carcinoma in fa...
-
Video Capsule Endoscopy in Familial Adenomatous Polyposis: Capsule Entrapment in an Anal StenosisA 44-year-old woman with familial adenom...