Jejunal Cancer in Patients with Familial Adenomatous Polyposis | oneFAPvoice

welcome to oneFAPvoice

- a positively charged Familial Adenomatous Polyposis community.
  • join today!
scientific articles

Jejunal Cancer in Patients with Familial Adenomatous Polyposis

key information

source: Clinical gastroenterology and hepatology

year: 2010

authors: Sinha A, Neale K F, Phillips R K, Clark S K

summary/abstract:

We read with interest the article by Ruys et al, regarding jejunal cancer in familial adenomatous polyposis (FAP) and their suggestion of jejunal surveillance. There have also been recent reports of capsule endoscopy revealing diminutive jejunal polyps in patients with FAP.

In our experience and in the literature, jejunal and ileal adenomas do not result in significant clinical problems in FA except within ileoanal pouches or associated with ileostomies. Small bowel polyps are more common in other inherited polyposis syndromes, particularly Peutz–Jeghers polyposis, where they often cause small bowel obstruction by intussusception. There exists only 1 case report of intussusception due to jejunal polyps occurring in a postcolectomy FAP patient. Jejunal cancer has also been reported very infrequently in FAP, with only 3 cases being identified in the current study. In our series of 591 FAP patients undergoing primary surgery at our institution, only 1 patient developed a confirmed jejunal cancer, at the age of 52 years. These data suggest that clinically significant jejunal polyps are extremely rare in FAP. There is no relevant clinical issue to justify routine surveillance.

DOI: 10.1016/j.cgh.2010.05.025

read more full text source

expertly curated content related to this topic

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close