welcome to oneFAPvoice- a positively charged Familial Adenomatous Polyposis community.
- join today!
Long-Term Outcome of Metachronous Rectal Cancer Following Ileorectal Anastomosis for Familial Adenomatous Polyposis
source: Journal of gastrointestinal surgery
authors: Tomohiro Yamaguchi, Seiichiro Yamamoto, Shin Fujita, Takayuki Akasu, Yoshihiro Moriyasummary/abstract:
BACKGROUND : Total colectomy with ileorectal anastomosis (IRA) for familial adenomatous polyposis (FAP) carries a potential risk of metachronous cancer in the residual rectum. This study evaluated the risk of cancer development in the residual rectum.
METHODS : Ninety-six patients who underwent initial surgery for prevention and cure of FAP were studied, and a clinicopathologic comparison was conducted between 59 patients who underwent IRA and 24 who underwent total proctocolectomy.
RESULTS : The 5-year overall survival rates were 94% after IRA and 95% after total proctocolectomy with no significant difference. The incidence of dense-type rectal polyps (4/17, 24%) was significantly higher in patients who developed metachronous rectal cancer following IRA compared to that in patients who did not (1/39, 3%). Moreover, 60% of patients with dense-type colon polyps developed metachronous rectal cancer compared to 24% in patients without and 80% of those with dense type rectal polyps developed metachronous rectal cancer compared to 25% without. Endoscopic surveillance of the eight Tis or T1 patients was performed at intervals of 6 months to 1 year after IRA but was not performed in three T3 patients for more than 2 years.
CONCLUSIONS : Effective IRA requires selection of patients without invasive rectal cancer and without dense rectal polyps in whom long-term postoperative follow-up of the residual rectum is possible.organization: Chuo-ku National Cancer Center Hospital
read more full text source
expertly curated content related to this topic
Summertime and FAP – An Interview with Tracy WhittI was lucky enough to spend a little ti...
Familial Adenomatous Polyposis in Three Generations of a Single Family: A Case StudyBACKGROUND : Familial adenomatous polypo...
5 Things to Know When You’re Dating a Person With an OstomyMaybe we told you about this months ago ...
20 Foods That Help Prevent Colon Cancer and Rectal CancerThis section of HealWithFood.org's Guide...
The FAP Handbook for Holiday FeastingWhether it’s tofurkey, turducken, or s...
“waiting to get a colonoscopy was my biggest mistake” my familial adenomatous polyposis storyI went to the Mayo Clinic in Rochester, ...
Enhanced Recovery Protocol for Colectomy Patients Reduced Hospital StayMultihospital collaboration and implemen...