welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Molecular Genetics of Supernumerary Tooth Formation
source: Genesis
year: 2011
authors: Wang X P, Fan J
summary/abstract:Despite advances in the knowledge of tooth morphogenesis and differentiation, relatively little is known about the aetiology and molecular mechanisms underlying supernumerary tooth formation. A small number of supernumerary teeth may be a common developmental dental anomaly, while multiple supernumerary teeth usually have a genetic component and they are sometimes thought to represent a partial third dentition in humans. Mice, which are commonly used for studying tooth development, only exhibit one dentition, with very few mouse models exhibiting supernumerary teeth similar to those in humans. Inactivation of Apc or forced activation of Wnt/β(catenin signalling results in multiple supernumerary tooth formation in both humans and in mice, but the key genes in these pathways are not very clear. Analysis of other model systems with continuous tooth replacement or secondary tooth formation, such as fish, snake, lizard, and ferret, is providing insights into the molecular and cellular mechanisms underlying succesional tooth development, and will assist in the studies on supernumerary tooth formation in humans. This information, together with the advances in stem cell biology and tissue engineering, will pave ways for the tooth regeneration and tooth bioengineering.
organization: Harvard UniversityDOI: 10.1002/dvg.20715
read more full text source
expertly curated content related to this topic
-
The Natural History of Familial Adenomatous Polyposis Syndrome: A 24 Year Review of a Single Center Experience in Sc...PURPOSE : Understanding the natural hist...
-
Successful Radiofrequency Ablation of an Anterior Abdominal Wall Desmoid in Familial Adenomatous PolyposisBACKGROUND : Desmoid tumours are an impo...
-
Thyroid Carcinoma in Patients with Familial Adenomatous PolyposisThere has been a growing awareness of th...
-
Familial Adenomatous Polyposis-Associated, Cribriform Morular Variant of Papillary Thyroid Carcinoma Harboring a K-R...BACKGROUND : The cribriform morular vari...
-
Phoebe’s Pledge – Inspirational teenager asking North East businesses to support young people with cancerPhoebe Hedley, from Cleadon, South Tynes...
-
Our Experience of Treatment of Cribriform Morular Variant of Papillary Thyroid Carcinoma; Difference in Clinicopatho...Cribriform-morular variant (CMV) is a co...
-
Prospective Randomized Study of Sulindac versus Calcium and Calciferol for Upper Gastrointestinal Polyps in Familial...Eighteen patients with familial adenomat...