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More Than Two Decades of APC Modeling in Rodents
source: Biochimica et biophysica acta
authors: Zeineldin M, Neufeld K Lsummary/abstract:
Mutation of tumor suppressor gene adenomatous polyposis coli (APC) is an initiating step in most colon cancers. This review summarizes Apc models in mice and rats, with particular concentration on those most recently developed, phenotypic variation among different models, and genotype/phenotype correlations.organization: University of Kansas
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