welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Mucosectomy with Handsewn Anastomosis Reduces the Risk of Adenoma Formation in the Anorectal Segment After Restorative Proctocolectomy for Familial Adenomatous Polyposis
source: Annals of surgery
year: 2011
authors: Alexander C. von Roon, Olivia C. C. Will, Ripple F. Man, Kay F. Neale, John R. Nicholls, Susan K. Clark, Robin K. S. Phillips, Paris P. Tekkis
summary/abstract:OBJECTIVE : The study compared the risk of adenoma or carcinoma formation in the anorectal segment after either mucosectomy with manual anastomosis or stapled ileoanal anastomosis (IAA) following restorative proctocolectomy (RPC) for familial adenomatous polyposis (FAP).
BACKGROUND : Few data exist on the risk of adenoma formation after either technique in FAP.
METHODS : All endoscopy and histology reports for patients having RPC for FAP attending for annual pouchoscopy from 1978 to 2007 were reviewed. The incidence, timing, and histological characteristics of adenoma or carcinoma formation were recorded.
RESULTS : Of the 206 patients, 140 attended for endoscopic follow-up for a median of 10.3 years after RPC. Fifty-two patients developed neoplastic transformation in the anorectal segment, with a cumulative risk at 10 years of 22.6% after mucosectomy with manual anastomosis and 51.1% after stapled IAA (P < 0.001). The median time to first adenoma was longer after mucosectomy with handsewn anastomosis than after stapled IAA (10.1 vs 6.5 years, P < 0.001). On multivariate analysis, stapled IAA (hazard ratio= 3.45, 95% confidence interval = 1.01–4.98) and age at RPC older than 40 years (hazard ratio = 2.20, 95% confidence interval = 1.01–4.89) were significantly associated with increased risk of adenoma formation. Nine patients developed a large (>10 mm) adenoma. One patient (handsewn ileoanal anastomosis) developed adenocarcinoma in the anorectal mucosa at 13 years and required pouch excision.
CONCLUSIONS : Adenoma formation in the anorectal mucosa after RPC for FAP is common but carcinoma is rare. The risk is lower after mucosectomy with handsewn anastomosis than after stapled IAA. Regular endoscopic surveillance after either technique is mandatory.
organization: St Mark’s Hospital LondonDOI: 10.1097/SLA.0b013e318f3f498
read more
expertly curated content related to this topic
-
Colorectal Cancer: No Longer the Issue in Familial Adenomatous Polyposis?Familial adenomatous polyposis (FAP) is ...
-
Jon Olis’s StoryAfter being misdiagnosed with hemorrhoid...
-
Attitudes Toward Genetic Testing in Childhood and Reproductive Decision-Making for Familial Adenomatous PolyposisChildhood DNA testing, prenatal diagnosi...
-
Shattering Cancer with Resonant Frequencies: Anthony Holland at TEDx Skidmore Collegehttps://www.youtube.com/watch?v=1w0_kazb...
-
Nexavar Narrative: 7 Month Updatehttps://www.youtube.com/watch?v=4I3D66vr...
-
Influence of Sulindac and Probiotics on the Development of Pouch Adenomas in Patients With Familial Adenomatous Poly...The purpose of this study is to determin...
-
Evaluation of 28 Years of Surgical Treatment of Children and Young Adults with Familial Adenomatous PolyposisBACKGROUND : In this retrospective study...