Multiple Neoplasia in a 15-Year-Old Girl with Familial Adenomatous Polyposis | oneFAPvoice

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scientific articles

Multiple Neoplasia in a 15-Year-Old Girl with Familial Adenomatous Polyposis

key information

source: Journal of pediatric hematology/oncology

year: 2009

authors: Benoit Brasseur, Karin Dahan, Véronique Beauloye, Noella Blétard, Sophie Dupont, Jean-Luc Guarin, Christophe Chantrain, Christiane Vermylen

summary/abstract:

A 15-year-old girl with adenomatous polyposis coli gene (APC) mutation and brain tumor-polyposis syndrome developed an unusual succession of cervicocephalic tumors (medulloblastoma, meningeal low-grade myxoid tumor, and papillary thyroid carcinoma), at the age of 5, 9, and 15 years, respectively. We discuss the genetic profile of the thyroid tumor in which a large somatic deletion of APC gene was found and the physiopathology of thyroid carcinoma in patients with germline APC mutation. We also point out the uncommon phenotype in this young girl with early multiple neoplasias and the difficulties of management of such familial adenomatous polyposis patients with occurrence of extracolonic cancers that require the use of potential trigger agents as radiotherapy or chemotherapy.

organisation: Catholic University of Louvain

DOI: 10.1097/MPH.0b013e3181984f91

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