welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
MUTYH-Associated Polyposis
source: Best practice & research: Clinical gastroenterology
year: 2009
authors: Julian R. Sampson, Natalie Jones
summary/abstract:MUTYH-associated polyposis (MAP) is an autosomal recessive disorder characterised by adenomatous polyps of the colorectum and a very high risk of colorectal cancer. It appears to be at least as prevalent as autosomal dominant familial adenomatous polyposis (that is caused by truncating mutations in the APC gene) with which it shares important gastroenterological features. It was first recognised as recently as 2002 and its full phenotype and natural history are still being characterised. Key extracolonic manifestations include a predisposition to duodenal adenomas and cancer and a modest increase in risk for several extraintestinal tumours. Testing for mutations in the MUTYH gene is indicated in patients who have multiple colorectal adenomas or a family history suggestive of autosomal recessive colorectal cancer and for the siblings and spouses of patients with MAP in order to inform surveillance and treatment for patients and their families.
organization: Cardiff UniversityDOI: 10.1016/j.bpg.2009.03.006
read more full text source
expertly curated content related to this topic
-
Familial Adenomatous Polyposis: Disease Basics from Cancer.NetClassic Familial Adenomatous Polyposis, ...
-
Screening for Thyroid Cancer in Patients with Familial Adenomatous PolyposisOBJECTIVE : Clarify the incidence of thy...
-
Biology of Colorectal CancerColorectal cancer is a serious health pr...
-
Familial Adenomatous Polyposis: Johns Hopkins Guide to the Diagnosis, Treatment and Prevention of ConditionMany patients with colorectal cancer exp...
-
Hereditary Colorectal Cancer Syndromes: American Society of Clinical Oncology Clinical Practice Guideline Endorsemen...Purpose: To provide recommendations on ...
-
Colorectal Cancer GuidelinesThe American Society of Colon and Rectal...
-
Clinical Practice Guidelines for the Prevention, Early Detection and Management of Colorectal CancerExecutive Summary Colorectal Cancer con...